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Könyv Affinity And Efficacy: The Components Of Drug-receptor Interactions Frederick J. Ehlert

Affinity And Efficacy: The Components Of Drug-receptor Interactions

Szerző: Frederick J. Ehlert
Nyelv: Angol
Kötés: Kemény kötésű
Kiadó: World Scientific Publishing Co Pte Ltd
Elérhetőség: Beszállítói készleten
Küldés 14-21 napon belül
108 537 Ft
The interaction of a drug with a receptor encodes a vector of information having components of affin...

Információk a könyvről

Szerző
Frederick J. Ehlert
Nyelv
Angol
Kötés
Könyv - Kemény kötésű
Kiadva
2014
oldal
752
EAN
9789814322560
ISBN
9814322563
Enbook ID
05070241
Kiadó
World Scientific Publishing Co Pte Ltd
Súly
1332
Méretek
161 x 237 x 37

Teljes leírás

The interaction of a drug with a receptor encodes a vector of information having components of affinity and efficacy. How this information is translated into a response depends on the unique cells, tissue, organ or system in which the receptor resides. This book describes how to analyze various responses to estimate the affinity and efficacy components of the initial drug-receptor interaction. More specifically, it describes how to measure the affinity and efficacy of drugs through the analysis of single receptor activity, the activation state of a population of receptors, and responses downstream from receptor activation. More light is shed on ligand-gated ion channels and G protein-coupled receptors in this book. The topics discussed include radio ligand binding, estimation of agonist affinity and efficacy, competitive antagonism, inverse agonism, allosteric agonists and modulators, ligand-directed signaling, modulation of pathway selectivity, and the analysis of the loss of function in tissues from receptor knockout mice. The natural history and structure of ligand-gated ion channels, G proteins, and G protein-coupled receptors are also discussed.

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