Analysis of cellular resistance mechanisms to viral oncolysis

Name: Analysis of cellular resistance mechanisms to viral oncolysis
Brand: Sudwestdeutscher Verlag Fur Hochschulschriften AG
SKU: 9783838124858
Price: 24151 HUF
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Szerző: Robert Strauss

Nyelv:

Kötés: Puha kötésű

Kiadó: Sudwestdeutscher Verlag Fur Hochschulschriften AG

Elérhetőség: Beszállítói készleten

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Vectors based on adenoviruses have been designed as targeted anti-cancer therapeutics that showed pr...

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Szerző

Robert Strauss

Nyelv

Német

Kötés

Könyv - Puha kötésű

Kiadva

2011

oldal

140

EAN

9783838124858

ISBN

3838124855

Enbook ID

07094646

Kiadó

Sudwestdeutscher Verlag Fur Hochschulschriften AG

Súly

213

Méretek

152 x 229 x 8

Teljes leírás

Vectors based on adenoviruses have been designed as targeted anti-cancer therapeutics that showed promising results in pre-clinical applications. Particularly, efforts have focused on the development of oncolytic vectors that can eliminate cancer cells and replicate in a tumor-selective fashion to amplify the input dose. In clinical trials, these oncolytic adenoviruses have generally been proved safe in patients, but have fallen short of their expected therapeutic value as monotherapies. A number of obstacles that hamper the efficacy of adenoviral vectors have been identified. These include several soluble and cellular blood components, the lack of viral receptors, and the extracellular matrix sequestered by tumor stroma. However, the apparent inability of adenoviruses to spread throughout solid tumors could not be fully explained yet. The work in this book sheds light on obstacles that previously had not been taken into account. It was identified that the epithelial phenotype of ovarian cancer cells represents a barrier for adenovirus infection and virus-mediated oncolysis. Furthermore, major discrepancies between phenotypes of tumors in situ and cultured cells were discovered.

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Analysis of cellular resistance mechanisms to viral oncolysis

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