Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)

Name: Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)
Brand: Springer Verlag, Singapore
SKU: 9789811092213
Price: 39684 HUF
Availability: InStock

Thiol "Switch-on" Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents

Szerző: TAOTAO ZOU

Nyelv:

Kötés: Puha kötésű

Kiadó: Springer Verlag, Singapore

Elérhetőség: Beszállítói készleten

Küldés 5-8 napon belül

39 684 Ft

This thesis focuses on the development of gold- and non-classical platinum-based anti-cancer agents...

Információk a könyvről

Szerző

TAOTAO ZOU

Nyelv

Angol

Kötés

Könyv - Puha kötésű

Kiadva

2018

oldal

164

EAN

9789811092213

ISBN

9789811092213

Enbook ID

19434379

Kiadó

Springer Verlag, Singapore

Súly

2818

Méretek

155 x 235 x 11

Teljes leírás

This thesis focuses on the development of gold- and non-classical platinum-based anti-cancer agents that display distinctively different anti-cancer mechanisms compared to the commonly used cisplatin. These metal complexes contain N-heterocyclic carbene (NHC) ligands which are able to form strong M-C(NHC) bonds, conferring high stability and favorable lipophilicity, reactivity and binding specificity of metal complexes on biomolecules. The author demonstrates significant advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. Detailed chemical synthesis, in vitro and/or in vivo anti-cancer activities are clearly presented including: (i) a class of Au(III) complexes containing a highly fluorescent N^N^N ligand and NHC ligand that simultaneously act as fluorescent thiol "switch-on" probes and anti-cancer agents; (ii) a dinuclear gold(I) complex with a mixed diphosphine and bis(NHC) ligand displaying favorable stability and showing significant inhibition of tumor growth in two independent mice models with no observable side effects; and (iii) a panel of stable luminescent cyclometalated platinum(II) complexes exhibiting high specificity to localize to the endoplasmic reticulum (ER) domain, inducing ER stress and cell apoptosis. These works highlight the clinical potential that gold and platinum complexes offer for cancer treatment.

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Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)

Thiol "Switch-on" Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents

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Teljes leírás

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