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Könyv ATORVASTATIN SELF-EMULSIFIED TABLETS FORMULATION AND EVALUATION Prafulla Kumar Sahu

ATORVASTATIN SELF-EMULSIFIED TABLETS FORMULATION AND EVALUATION

Szerző: Prafulla Kumar Sahu
Nyelv: Angol
Kötés: Puha kötésű
Kiadó: LAP LAMBERT Academic Publishing
Elérhetőség: Beszállítói készleten
Küldés 8-11 napon belül
14 678 Ft
Due to poor drug solubility and absorption, many drug candidates fall short of expectations. Self-em...

Információk a könyvről

Szerző
Prafulla Kumar Sahu
Nyelv
Angol
Kötés
Könyv - Puha kötésű
Kiadva
2022
oldal
76
EAN
9786205528082
ISBN
6205528088
Enbook ID
42835871
Kiadó
LAP LAMBERT Academic Publishing
Súly
131
Méretek
150 x 220 x 5

Teljes leírás

Due to poor drug solubility and absorption, many drug candidates fall short of expectations. Self-emulsifying drug delivery methods increase the solubility and bioavailability of poorly soluble medications. When SEDDS are added to an aqueous phase and gently mixed, fine oil-in-water emulsions form. SEDDS come in soft or hard gelatin capsules for oral administration and form fine, stable oil-in-water emulsions. SEDDS are primarily manufactured as liquid formulations, which have poor stability and mobility, low drug loading, a limited number of dosage form options, irreversible drug/excipient precipitation, and a high proportion (30-60%) of surfactants that might irritate the gastrointestinal system. Solid-SEDDS has been studied to avoid the problems of liquid SEDDS. The adsorption of liquid self-micro-emulsified formulations on solid carriers is one of the best ways to create free-flowing powders for compression into tablet dosage form (SMET).

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