Brain - from Development to Neoplasia, and Gene Therapy Solution

Name: Brain - from Development to Neoplasia, and Gene Therapy Solution
Brand: LAP Lambert Academic Publishing
SKU: 9786202080248
Price: 22247 HUF
Availability: InStock

Szerző: Jerzy Trojan

Nyelv:

Kötés: Puha kötésű

Kiadó: LAP Lambert Academic Publishing

Elérhetőség: Beszállítói készleten

Küldés 5-8 napon belül

22 247 Ft

Differentiation of nervous tissue, which occurs during CNS development, was first described in detai...

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Szerző

Jerzy Trojan

Nyelv

Angol

Kötés

Könyv - Puha kötésű

Kiadva

2017

oldal

156

EAN

9786202080248

Enbook ID

18732514

Kiadó

LAP Lambert Academic Publishing

Súly

250

Méretek

150 x 220 x 9

Teljes leírás

Differentiation of nervous tissue, which occurs during CNS development, was first described in detail while investigating a model of rat brain through the use of a new biomarker known as alpha-fetoprotein, AFP. During this research, another model -mouse teratocarcinoma - enabled the description of the different steps of nervous tissue formation following distinct pathological ways of CNS development. Comparing these two processes gave rise to the following conclusions: a striking convergence exists between normal and neoplastic nervous tissue development and correlates with the presence of oncoproteins such as AFP and growth factor IGF-I. These interesting observations have oriented the pursuit of one goal: stopping the neoplastic CNS development conducing to the malignant tumor - glioblastoma. From this endeavor, stemmed an efficient anti-gene strategy targeting gene of growth factor IGF-I present in brain tumor development, inducing immune anti-tumor response and consequently, increasing the median survival of glioblastoma patients up to 2 years.

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Brain - from Development to Neoplasia, and Gene Therapy Solution

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