Cellular prion protein (PrPC) in Caenorhabditis elegans

Name: Cellular prion protein (PrPC) in Caenorhabditis elegans
Brand: Sudwestdeutscher Verlag Fur Hochschulschriften AG
SKU: 9783838125060
Price: 23974 HUF
Availability: InStock

Szerző: Marcel Werner Stahl

Nyelv:

Kötés: Puha kötésű

Kiadó: Sudwestdeutscher Verlag Fur Hochschulschriften AG

Elérhetőség: Beszállítói készleten

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Cellular prion protein (PrPC) is a conserved glycoprotein predominantly being expressed in neurons,...

Információk a könyvről

Szerző

Marcel Werner Stahl

Nyelv

Angol

Kötés

Könyv - Puha kötésű

Kiadva

2012

oldal

144

EAN

9783838125060

ISBN

3838125061

Enbook ID

07093728

Kiadó

Sudwestdeutscher Verlag Fur Hochschulschriften AG

Súly

222

Méretek

152 x 229 x 9

Teljes leírás

Cellular prion protein (PrPC) is a conserved glycoprotein predominantly being expressed in neurons, glial and lymphatic cells. While the pathology of prion diseases based on the misfolded Scrapie prion protein (PrPSc) is well understood, the physiologic function of PrPC remains enigmatic. Therefore, its much debated function in oxidative stress resistance was further investigated by expressing human PrPC in Caenorhabditis elegans (C. elegans). Both under non stressful conditions and under Paraquat exposure, a producer of superoxide anions, nematodes expressing PrPC had a significant increase in lifespan and stress resistance. Interactions with established C. elegans stress pathways were excluded. However, expression of PrPC showed no effect in handling other stressors like hydrogen peroxide, heat and copper ions intoxication. Further testing showed Paraquat resistance being SOD-1 (superoxide dismutase) dependent. However, advantageous resistance of PrPC strains is only achieved via SOD-4 and SOD-5 expression, therefore strongly suggesting that additional resistance of PrPC strains is caused by SOD-1 overexpression, regulated by the potential regulator enzymes SOD-4 and SOD-5.

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Cellular prion protein (PrPC) in Caenorhabditis elegans

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