Menu
Rendelés állapotának ellenőrzése
Kapcsolat
Könyv Chiral Separations Gerald Gübitz

Chiral Separations

Methods and Protocols

Szerző: Gerald Gübitz, Martin G. Schmid
Nyelv: Angol
Kötés: Kemény kötésű
Kiadó: Humana Press Inc.
Elérhetőség: Beszállítói készleten
Küldés 10-13 napon belül
38 357 Ft
Many compounds of biological and pharmacological interest are as- metric and show optical activity....

Információk a könyvről

Szerző
Gerald Gübitz, Martin G. Schmid
Nyelv
Angol
Kötés
Könyv - Kemény kötésű
Kiadva
2003
oldal
432
EAN
9781588291509
ISBN
1588291502
Enbook ID
01430250
Kiadó
Humana Press Inc.
Súly
916
Méretek
155 x 235 x 32

Teljes leírás

Many compounds of biological and pharmacological interest are as- metric and show optical activity. Approximately 40% of the drugs in use are known to be chiral and only about 25% are administered as pure enantiomers. It is well established that the pharmacological activity is mostly restricted to one of the enantiomers (eutomer). In several cases, unwanted side effects or even toxic effects may occur with the inactive enantiomer (distomer). Even if the side effects are not that drastic, the inactive enantiomer has to be meta- lized, which represents an unnecessary burden for the organism. The admin- tration of pure, pharmacologically active enantiomers is therefore of great importance. The ideal way to get to pure enantiomers would be by enantioselective synthesis. However, this approach is usually expensive and not often practicable. Usually, the racemates are obtained in a synthesis, and the separation of the enantiomers on a preparative scale is necessary. On the other hand, there is also a great demand for methods of enantiomer separation on an analytical scale for controlling synthesis, checking for racemization p- cesses, controlling enantiomeric purity, and for pharmacokinetic studies. C- ventional methods for enantiomer separation on a preparative scale are fractionated crystallization, the formation of diastereomeric pairs followed by repeated recrystallization, and enzymatic procedures. In recent years, ch- matographic methods such as gas chromatography and, especially, liquid ch- matography have attracted increasing interest for chiral separation, both on analytical and preparative scales.

Érdekelheti

Studies on Arthritis and Joint Disorders

Maria Jose Alcaraz
75 074 Ft

Asian American History A Very Short Introduction

Hsu
4 007 Ft

Dynamics of Heterogeneous Materials

Vitali Nesterenko
60 879 Ft

Research and Technical Writing for Science and Engineering

Qiu
61 491 Ft

Ueda Sensei Castrates the Insidious Underground

Robert Crayola
4 502 Ft

To what extent rape and sexual violence should be considered a tool of genocide

Alexander Syder
5 409 Ft

Information Technology Investment: Decision Making Methodology

Mare J. Schniederjans
48 827 Ft

Wings Over New Orleans

John Taylor
5 199 Ft

Seven Deadly Needs

Edward Bear
4 945 Ft

Researching for the Media

Adele Emm
76 731 Ft

Touchstone Level 4 Workbook

Michael McCarthyJeanne McCartenHelen Sandiford
6 120 Ft

Electrorheological Fluids: Modeling and Mathematical Theory

Michael Ruzicka
19 234 Ft

Azok a vásárlók, akik ezt a könyvet megvásárolták, a következőket is megvásárolták

Estetica e romanzo

Michail Bachtin
11 078 Ft

Entdecke deine Schönheit

Deepak Chopra
6 544 Ft

Das Leben Des Weltmeeres

Ernst Hentschel
19 761 Ft

Spravedlnost

Lee Child
7 268 Ft

SOLO UNO

STEPHEN PRATT
8 599 Ft

Am anderen Ufer

Herbert A. Rößler
4 391 Ft