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Könyv Coated Implant Surfaces Petra M. Dorfner

Coated Implant Surfaces

Influence of RGD Coating in Combination with Surface Properties on the Adhesion Process of Osteoblasts

Szerző: Petra M. Dorfner
Nyelv: Angol
Kötés: Puha kötésű
Kiadó: Sudwestdeutscher Verlag Fur Hochschulschriften AG
Elérhetőség: Beszállítói készleten
Küldés 8-11 napon belül
23 357 Ft
A profound knowledge of bony in growth is the basis for the development of biofunctionalized implant...

Információk a könyvről

Szerző
Petra M. Dorfner
Nyelv
Angol
Kötés
Könyv - Puha kötésű
Kiadva
2012
oldal
140
EAN
9783838135106
ISBN
3838135105
Enbook ID
06920641
Kiadó
Sudwestdeutscher Verlag Fur Hochschulschriften AG
Súly
213
Méretek
152 x 229 x 8

Teljes leírás

A profound knowledge of bony in growth is the basis for the development of biofunctionalized implants. The positive influence of RGD peptides and surface properties of implant material on cell adhesion is well known. With the aim to reveal potential synergies, we functionalized different Ti6Al4V disks with highly active v-specific RGD peptides. Our integrin binding studies yielded the most promising results for the combination of peptide coating and rough surfaces. Cell adhesion experiments performed with characterized human primary osteoblasts demonstrated that cells adhere more strongly on rough surfaces coated with peptide compared to smooth ones. We showed that peptide coating and surface topography influence the adhesion kinetics particularly at the early stage. Cell spreading was accelerated on Ti6Al4V disks immobilized with peptides within the first hour, while after longer incubation times this effect is less pronounced. The combination of RGD peptide coating with optimized topological surface properties of implant materials bears the potential to increase osseointegration.

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