Könyv Daptomycin Oligomers Action versus Gram-positive Bacteria Jawad Kadhum Muraih

Daptomycin Oligomers Action versus Gram-positive Bacteria

Nyelv: Angol
Kötés: Puha kötésű
Elérhetőség: Beszállítói készleten
Küldés 5-8 napon belül
17 180 Ft
Daptomycin is a lipopeptide antibiotic that contains 13 amino acids and an N-terminally attached fat...

Információk a könyvről

Nyelv
Angol
Kötés
Könyv - Puha kötésű
Kiadva
2017
oldal
124
EAN
9786202027748
Enbook ID
18367163
Súly
203
Méretek
150 x 220 x 7

Teljes leírás

Daptomycin is a lipopeptide antibiotic that contains 13 amino acids and an N-terminally attached fatty acyl residue. The antibiotic kills Gram-positive bacteria by membrane depolarization. It has long been assumed that the mode of action of daptomycin involves the formation of oligomers on the bacterial cell membrane; fluorescence energy transfer (FRET) is used between native daptomycin and an NBD-labeled daptomycin derivative to demonstrate that the antibiotic indeed forms oligomers on bacterial cell membranes. In a liposome model, oligomer formation depends on calcium and on phosphatidylglycerol (PG).Furthermore, membrane permeabilization is selective, and electron microscopy of bacterial membranes exposed to daptomycin has revealed no discontinuities or accretions of electron density.

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