Könyv Design, Development and Evaluation of Mucoadhesive Nanoemulsion Drugs Mahesh Wagh

Design, Development and Evaluation of Mucoadhesive Nanoemulsion Drugs

Szerző: Mahesh Wagh
Nyelv: Angol
Kötés: Puha kötésű
Elérhetőség: Beszállítói készleten
Küldés 5-8 napon belül
31 870 Ft
The study aimed to create and assess mucoadhesive nanoemulsion-based drug delivery systems (MNEs) fo...

Információk a könyvről

Szerző
Nyelv
Angol
Kötés
Könyv - Puha kötésű
Kiadva
2024
oldal
264
EAN
9786208064846
ISBN
6208064848
Enbook ID
46704467
Súly
411
Méretek
150 x 220 x 16

Teljes leírás

The study aimed to create and assess mucoadhesive nanoemulsion-based drug delivery systems (MNEs) for the effective delivery of antimigraine agents into the central nervous system (CNS). The research investigated three categories of drugs: triptans, beta-blockers, and ACE inhibitors, focusing on their potential to improve therapeutic outcomes for migraine treatment. Drug Selected were Triptans: Sumatriptan, Zolmitriptan, Almotriptan, Beta-Blockers: Propranolol, Timolol, Nadolol, ACE Inhibitors : Captopril, Enalapril, Lisinopril Nanoemulsion FormulationMNEs were prepared using standard nanoemulsion techniques, incorporating mucoadhesive polymers to enhance retention in the nasal cavity.The formulations were evaluated for drug release profiles, mucoadhesive strength, and stability.Results Triptans- Sumatriptan: MNEs showed acumulative drug release of 83.43% after 8 hours.- Zolmitriptan:MNEs exhibited acumulative drug release of 83.63% after 8 hours.- Almotriptan: Demonstrated the highest cumulative drug releaseat89.04% after 8 hours.Overall, MNEs significantly improved drug release for all triptans compared to traditional NEs and plain drug solutions (PDS).

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