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Könyv Diabetes Mellitus Yusaku Nakabeppu

Diabetes Mellitus

A risk factor for Alzheimer's Disease

Szerző: Yusaku Nakabeppu, Toshiharu Ninomiya
Nyelv: Angol
Kötés: Kemény kötésű
Kiadó: Springer Verlag, Singapore
Elérhetőség: Beszállítói készleten
Küldés 10-13 napon belül
54 524 Ft
This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) ac...

Információk a könyvről

Szerző
Yusaku Nakabeppu, Toshiharu Ninomiya
Nyelv
Angol
Kötés
Könyv - Kemény kötésű
Kiadva
2019
oldal
248
EAN
9789811335396
Enbook ID
20565860
Kiadó
Springer Verlag, Singapore
Súly
649
Méretek
155 x 235 x 19

Teljes leírás

This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer's disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore in depth the mechanisms involved in this relationship, including abnormal protein processing, dysregulated glucose metabolism, impaired insulin signaling, and mitochondrial dysfunction. The molecular interactions between diabetes and AD are fully discussed, highlighting the pathological molecular mechanisms induced by diabetes that promote and accelerate AD pathology. Finally, diagnostic biomarkers and potential therapeutic approaches for AD are considered on the basis of the presented evidence. In providing answers to the critical questions of whether and why DM is a risk factor for AD, this book will hold appeal for a wide interdisciplinary audience.

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