This book covers key emerging technologies - detailed under About the Topic - in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development.New technologies and tools to guide drugs through the discovery process§Most drugs never leave the laboratory as a result of failure to predict efficacy and safety. In response, this book offers readers an array of new and emerging technologies. These technologies arm pharmaceutical scientists with more systematic and effective approaches for deciphering the complex interactions among chemistry, biology, and medicine, helping to ensure that more research efforts focus on drugs that can be successfully translated from the laboratory to the clinic and onto the market. Among the topics addressed in Drug Efficacy, Safety, and Biologics Discovery are:§High throughput protein-based technologies and computational models for drug development, efficacy, toxicity, systems pharmacology, biomarkers, biomolecular networks, computational systems biology modeling of dosimetry, cellular response pathways, nanotechnology to improve drug delivery, and modeling efficacy and safety of engineered biologics§Each of the fourteen chapters has been authored by one or more of the leading experts in the field. Their advice is not only based on a thorough review of the latest findings, but also their own firsthand experience in drug discovery and development. Extensive references guide readers to the literature for more in-depth investigations of particular topics.§By cutting across the many disciplines needed for successful drug discovery, this book suits the needs of all chemists, biologists, and technologists involved in drug discovery and development. Moreover, by advocating for cross-disciplinary collaboration, this book is certain to fuel future innovation in drug discovery.
