Efficient Two-Stage Model for Predicting Protein-Protein Interactions

Name: Efficient Two-Stage Model for Predicting Protein-Protein Interactions
Brand: VDM Verlag Dr. Müller
SKU: 9783639118582
Price: 17021 HUF
Availability: InStock

Machine Learning

Szerző: Jingkai Yu

Nyelv:

Kötés: Puha kötésű

Kiadó: VDM Verlag Dr. Müller

Elérhetőség: Kiadói készleten rendelésre

Küldés 17-27 napon belül

17 021 Ft

Genome sequencing have identified many predicted§proteins with §unknown biological functions. Protei...

Információk a könyvről

Szerző

Jingkai Yu

Nyelv

Angol

Kötés

Könyv - Puha kötésű

Kiadva

2009

oldal

116

EAN

9783639118582

Enbook ID

06820689

Kiadó

VDM Verlag Dr. Müller

Súly

189

Méretek

150 x 220 x 7

Teljes leírás

Genome sequencing have identified many predicted§proteins with §unknown biological functions. Protein interaction§networks link §proteins/genes together, provide a global context for§interacting §proteins, and enable studies at the systems level.§High throughput §methods were developed to detect protein-protein§interactions. §However, current techniques show high levels of false§positives and §false negatives. They are also labor intensive and§expensive to §perform. Computational methods are needed to reduce§testing §space and enhance testing efficiency. In this work, a§two-stage §statistical scoring model was built to assign§confidence scores to §fruit fly yeast two-hybrid interactions. High§confidence predictions §are significantly enriched with biologically§meaningful interactions. §Cross-validation showed good prediction performance,§which were §also validated by independent data sources. We§obtained 24798 new §interactions involving 4702 proteins. The work should§be especially §interesting to researchers in interactome or systems§biology fields. §It also appeals to professionals practicing machine§learning or data §mining in computational biology and bioinformatics.

Érdekelheti

Azok a vásárlók, akik ezt a könyvet megvásárolták, a következőket is megvásárolták

Leggyakrabban keresett

Categories

Authors

Publishers

Termékek

Termékek

Leggyakrabban keresett

Categories

Authors

Publishers

Termékek

Termékek

Efficient Two-Stage Model for Predicting Protein-Protein Interactions

Machine Learning

Információk a könyvről

Teljes leírás

Érdekelheti

Azok a vásárlók, akik ezt a könyvet megvásárolták, a következőket is megvásárolták