Endogenous Retroviruses, Autoimmunity and Multiple Sclerosis

Name: Endogenous Retroviruses, Autoimmunity and Multiple Sclerosis
Brand: LAP Lambert Academic Publishing
SKU: 9783659146190
Price: 28133 HUF
Availability: InStock

MSRV/HERV-W : Inflammatory and Immunological Actions

Szerző: Christina Lomparski

Nyelv:

Kötés: Puha kötésű

Kiadó: LAP Lambert Academic Publishing

Elérhetőség: Kiadói készleten rendelésre

Küldés 17-27 napon belül

28 133 Ft

Endogenous retroviruses (of the HERV-W family) represent about 8% (1%) of our genome. Their endogeno...

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Szerző

Christina Lomparski

Nyelv

Angol

Kötés

Könyv - Puha kötésű

Kiadva

2012

oldal

240

EAN

9783659146190

Enbook ID

06996678

Kiadó

LAP Lambert Academic Publishing

Súly

374

Méretek

150 x 220 x 14

Teljes leírás

Endogenous retroviruses (of the HERV-W family) represent about 8% (1%) of our genome. Their endogenous and exogenous forms (MSRV, Multiple Sclerosis-associated RetroVirus) can alter the regulation of the immune system and be involved in inflammatory and autoimmune pathologies (Multiple Sclerosis). The MSRV envelope protein (ENV) stimulates T lymphocytes by acting as a superantigen and interacts with monocytes and dendritic cells via membrane receptors, thereby provoking inflammatory cytokine production. The work presented in this thesis combines an in vitro cellular and molecular approach (immunological cascade from receptor interaction to pathology) with an in vivo validation using the mouse model Experimental Autoimmune Encephalomyelitis (EAE) in which the complete Freund's adjuvant can be replaced by ENV ; its effects are monitored by behavioural (clinical score), brain (MRI), cellular and molecular analysis. In order to create a transgenic mouse model expressing different ENVs (MSRV/HERV) ruled by different promoters, first steps of cloning have been done; behaviour, brain and immune system particularities of these mice shall be studied in futur works.

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Endogenous Retroviruses, Autoimmunity and Multiple Sclerosis

MSRV/HERV-W : Inflammatory and Immunological Actions

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