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Könyv Endothelium, Part II Michel Feletouaiai

Endothelium, Part II

EDHF-Mediated Responses ""The Classical Pathway

Szerző: Michel Feletouaiai
Nyelv: Angol
Kötés: Puha kötésű
Kiadó: Morgan & Claypool Publishers
Elérhetőség: Beszállítói készleten
Küldés 14-21 napon belül
31 333 Ft
The endothelium controls vascular tone by releasing various vasoactive substances. Additionally, ano...

Információk a könyvről

Szerző
Michel Feletouaiai
Nyelv
Angol
Kötés
Könyv - Puha kötésű
Kiadva
2010
oldal
306
EAN
9781615043378
ISBN
9781615043378
Enbook ID
06517103
Kiadó
Morgan & Claypool Publishers
Súly
377
Méretek
187 x 235 x 11

Teljes leírás

The endothelium controls vascular tone by releasing various vasoactive substances. Additionally, another pathway associated with the hyperpolarization of both endothelial and vascular smooth muscle cells contributes also to endothelium-dependent relaxations (EDHF-mediated responses). These responses involve an increase in the intracellular Ca concentration of the endothelial cells followed by the opening of Ca-activated K channels of small and intermediate conductances (SKCa and IKCa). These channels show a distinct subcellular distribution, suggesting that their activation could be elicited by distinct stimuli. Following KCa activation, the endothelial hyperpolarization can be conducted to the underlying smooth muscle cells by electrical coupling through myo-endothelial gap junctions. In addition, the potassium efflux can lead to the accumulation of potassium ions in the intercellular space and the subsequent activation of smooth muscle Kir2.1 and/or Na/K-ATPase. The hyperpolarization of the smooth muscle cells produces vascular relaxation, predominantly by closing voltage-gated calcium channels, and vasodilatation. EDHFmediated responses are altered in various pathologies or, conversely, act as a compensating mechanism when other endothelial pathways are impaired. A better characterization of EDHF-mediated responses should allow determining whether or not new drugable targets can be identified within this endothelial pathway for the treatment of cardiovascular diseases. Table of Contents: Endothelium-Dependent Hyperpolarizations: The Classical "EDHF" Pathway / Conclusion / References

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