Many global enterprises have encountered various changes, such as the progress of new technologies, globalization, shifts in customer needs and new business models. Important changes in cutting-edge IT technology with recent developments in Cloud computing and Mobile IT (such as progress in big data technology) have emerged as new trend these days. Enterprise Architecture can be effective because it contributes to the design of mid/large integrated systems, which show a major technical challenge toward the era of Cloud/Mobile IT/Digital IT in digital transformation. This book explains how to investigate solutions incorporated by Architecture Board in the Global Enterprise for solving issues and mitigating related architecture risks while proposing and implementing "Adaptive Integrated Digital Architecture Framework - AIDAF" and related models and approaches/platforms, which can be applied in companies promoting IT strategy using Cloud/Mobile IT/Digital IT/Big Data. As a final part of this book, in terms of "Internet of Things - IoT," the research project named "Open Healthcare Platform 2030" is introduced.