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Könyv Fetal Hemoglobin Nishant Chakravorty

Fetal Hemoglobin

The Panacea for Major -Hemoglobinopathies

Szerző: Nishant Chakravorty
Nyelv: Angol
Kötés: Kemény kötésű
Kiadó: Nova Science Publishers Inc
Elérhetőség: 50 % esély
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92 243 Ft
Intricate processes involved in perpetuating the multitude of physiological phenomena in the human b...

Információk a könyvről

Szerző
Nishant Chakravorty
Nyelv
Angol
Kötés
Könyv - Kemény kötésű
Kiadva
2020
oldal
355
EAN
9781536179552
ISBN
1536179558
Enbook ID
32922336
Kiadó
Nova Science Publishers Inc
Súly
612

Teljes leírás

Intricate processes involved in perpetuating the multitude of physiological phenomena in the human body often encounter aberrations and omissions in the genetic code of life. While such errors often lead to lethal diseases, at other times they provide distinctive survival advantages and thus unscramble cues to unconventional therapeutic strategies for life-threatening conditions. Hereditary Persistence of Fetal Hemoglobin (HPFH) is one such condition wherein the typically inactivated fetal form of hemoglobin (HbF) remains overexpressed even in adult stages of the bearer''s life. Strikingly, this condition is known to ameliorate pathological manifestations in patients with aberrant adult hemoglobin synthesis (e.g. β-hemoglobinopathies like β-thalassemia, sickle cell disease etc.). Early researchers in the field expected such patients to suffer from clinical challenges owing to HbF''s high affinity to oxygen and consequent difficulty in its release to cells and tissues. Surprisingly, these patients are known to lead a physiologically normal life. Modern-day hematologists and clinical researchers have looked-up to the concept of "HbF reactivation" as a potential curative strategy for patients suffering from β-hemoglobinopathies like β-thalassemia and sickle cell disease. As a result, several drugs like hydroxyurea, 5-azacytidine, cytosine arabinoside, natural products etc. have been tried in clinics to elevate HbF levels in such patients with limited success and poor understanding on the mechanisms of their action. Associated side-effects and complications of using cytotoxic agents like these restrict their use in most instances. Fortunately, with the advent of newer molecular tools and techniques, researchers are focusing their attention to reengineer the molecular machinery and thus reactivate the gamma-globin gene. This book brings together a selection of chapters dedicated to fetal hemoglobin -- its physiological role, regulation, methodologies to manipulate and future strategies. Researchers and scientists interested in the topic will have a comprehensive understanding of the current concepts on fetal hemoglobin modulation and therefore will serve as a launching pad for their research ideas.

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