Genomic Elements in Health, Disease and Evolution

Name: Genomic Elements in Health, Disease and Evolution
Brand: Springer-Verlag New York Inc.
SKU: 9781493943654
Price: 59362 HUF
Availability: InStock

Junk DNA

Szerző: Kyriacos Felekkis, Konstantinos Voskarides

Nyelv:

Kötés: Puha kötésű

Kiadó: Springer-Verlag New York Inc.

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Over 98% of the human genome contains non-coding DNA sequences. For many years molecular biologists...

Információk a könyvről

Szerző

Kyriacos Felekkis, Konstantinos Voskarides

Nyelv

Angol

Kötés

Könyv - Puha kötésű

Kiadva

2016

oldal

315

EAN

9781493943654

Enbook ID

18344527

Kiadó

Springer-Verlag New York Inc.

Súly

5575

Méretek

155 x 15 x 17

Teljes leírás

Over 98% of the human genome contains non-coding DNA sequences. For many years molecular biologists referred to this component of the genome as the "junk" DNA since it does not code for any "useful" protein product. Over the last years this notion changed significantly as scientists discovered that a large part of this DNA contains various genomic elements that have important roles in cell physiology. Genomic elements such as non-coding RNAs, transposons, splicing RNAs, DNA repeats and others were shown to play a significant role in regulating gene expression. In addition, all these elements were implicated to contribute in the pathogenesis or progression of various human diseases. In this book, the editor will attempt to describe all these genomic elements that constitute the junk DNA of the genome. For every genomic element, the physiologic role in the organism, its role in evolution and any possible involvement in human diseases will be discussed. Additionally, interaction between these elements in normal or pathologic condition will be discussed. Since a large amount of new knowledge is generated daily in regards to these genomic elements, this book will attempt to combine all the information in a single publication that can serve as a reference for future studies. The first part will discuss RNA elements such as microRNAs, long non-coding RNAs, piRNAs and splicing RNAs. The second part of the book will deal with transposons, retrotransposons and DNA transposons. Finally the third part of the book will discuss DNA elements that include DNA repeats, conserved non-coding sequences, distal genomic elements, introns, pseudogenes, CpG islands and telomeres. For miRNAs and CNVs a separate chapter will be dedicated to their role in human diseases since an extensive amount of information exists about these two elements.

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Genomic Elements in Health, Disease and Evolution

Junk DNA

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