Könyv Graph-based approaches to protein structure comparison Marco Mernberger

Graph-based approaches to protein structure comparison

Szerző: Marco Mernberger
Nyelv: Német
Kötés: Puha kötésű
Elérhetőség: Beszállítói készleten
Küldés 8-11 napon belül
29 752 Ft
The comparison of protein structures is a central task in structural bioinformatics. Drawing upon st...

Információk a könyvről

Nyelv
Német
Kötés
Könyv - Puha kötésű
Kiadva
2012
oldal
248
EAN
9783838134529
ISBN
3838134524
Enbook ID
07008919
Súly
367
Méretek
152 x 229 x 14

Teljes leírás

The comparison of protein structures is a central task in structural bioinformatics. Drawing upon structural information enables the inference of function for unknown proteins, even without apparent homology on the sequence level. Regarding enzyme function, the conformation of the catalytic site or the binding pocket accomodating bound substrates or ligands is especially interesting due to structural constraints imposed by the catalyzed reaction or the bound molecule. Hence, these sites are likely to be similar in proteins interacting with similar molecules. This is especially appealing in pharmaceutics as it allows for the prediction of cross reactivities prior to expensive clinical trials. In this book, Marco Mernberger gives an introduction to protein structure comparison with a special regard to protein binding pockets and developes different graph-based approaches based on global, local and semi-global strategies. As it is not apparent which principle is more suitable for the detection of cross reactivities, a comparative study is conducted, highlighting the advantages and drawbacks of local, global and semi-global methods.

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