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Könyv Hypoxia-Selective Copper Radiopharmaceuticals Jason Holland

Hypoxia-Selective Copper Radiopharmaceuticals

Rational Design of Novel Imaging Agents

Szerző: Jason Holland
Nyelv: Angol
Kötés: Puha kötésű
Kiadó: VDM Verlag
Elérhetőség: Kiadói készleten rendelésre
Küldés 17-27 napon belül
27 948 Ft
Solid tumours differ from normal tissue in a number§of important ways. Rapid growth and metabolism o...

Információk a könyvről

Szerző
Jason Holland
Nyelv
Angol
Kötés
Könyv - Puha kötésű
Kiadva
2009
oldal
272
EAN
9783639152449
ISBN
3639152441
Enbook ID
06823766
Kiadó
VDM Verlag
Súly
404
Méretek
152 x 229 x 15

Teljes leírás

Solid tumours differ from normal tissue in a number§of important ways. Rapid growth and metabolism of§tumours often leads to altered physiology including§changes in vasculature and perfusion which can in§turn induce fluctuations in the supply of nutrients§such as oxygen. Reduced tissue oxygenation, known as§hypoxia, has been linked to radio- and§chemotherapeutic resistance and is often associated§with a poor prognosis for disease-free survival in§cancer patients. §§Identification of tumour hypoxia by using§non-invasive imaging techniques such as positron§emission tomography (PET) is vital for clinicians to§provide effective treatment. However, physiological§imaging modalities such as PET require the design and§administration of radioactive imaging agents which§specifically target tumours. §§This book provides a background to the basic chemical§concepts and methods used in the rational design of§tumour-selective radiopharmaceuticals with particular§emphasis on the mechanisms by which§copper-based imaging agents target tumour hypoxia.

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