Könyv Interactions between membrane transporters and phospholipids Pierre Hakizimana

Interactions between membrane transporters and phospholipids

Nyelv: Angol
Kötés: Puha kötésű
Kiadó: VDM Verlag
Elérhetőség: Kiadói készleten rendelésre
Küldés 17-27 napon belül
17 604 Ft
Highly solved crystal structures and a wealth of§biochemical data are now available for an increasin...

Információk a könyvről

Nyelv
Angol
Kötés
Könyv - Puha kötésű
Kiadva
2009
oldal
92
EAN
9783639136708
ISBN
3639136705
Enbook ID
06822344
Kiadó
Súly
145
Méretek
152 x 229 x 6

Teljes leírás

Highly solved crystal structures and a wealth of§biochemical data are now available for an increasing§number of membrane proteins. However, the question of§how lipid molecules interact with integral membrane§proteins and regulate their structure and function in§biological membranes remains unsatisfactorily addressed. §This book discusses the functional mechanisms§of membrane proteins in general and the effect of the§surrounding lipidic environment, in the context of§recent developments in the field. Recent experimental§investigations on the proton gradient-driven§multidrug transporter LmrP are also discussed. Using§this membrane protein as a model, we demonstrated§that the protein structure and function was depending§on the phosphatidylethanolamine (PE) headgroup. We§then showed that a negatively charged residue, Asp68,§could participate in the interaction with PE and that§such interaction is required for proper activity and§structure of the protein. Because Asp-68 belongs to a§highly conserved motif of the Major Facilitator§Superfamily (MFS) , this interaction might be a§general feature of these transporters that is§involved in proton gradient sensing and lipid dependence.

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