Leptin, 1

Name: Leptin, 1
Brand: Springer, Berlin
SKU: 9783319099149
Price: 37775 HUF
Availability: InStock

Regulation and Clinical Applications

Szerző: Samuel Dagogo-Jack

Nyelv:

Kötés: Kemény kötésű

Kiadó: Springer, Berlin

Elérhetőség: Beszállítói készleten

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Twenty years after its discovery, recombinant human leptin has been approved by the Food and Drug Ad...

Információk a könyvről

Szerző

Samuel Dagogo-Jack

Nyelv

Angol

Kötés

Könyv - Kemény kötésű

Kiadva

2014

oldal

350

EAN

9783319099149

ISBN

3319099140

Enbook ID

05147755

Kiadó

Springer, Berlin

Súly

822

Méretek

178 x 254 x 16

Teljes leírás

Twenty years after its discovery, recombinant human leptin has been approved by the Food and Drug Administration for the treatment of patients with lipodystrophy. Beginning with a synthesis of the vast body of work on its discovery, dissection of mechanisms, and effects in experimental models , the focus of this book shifts to a consideration of the regulation and role of leptin in humans. The emphasis on human-level data is a unique feature of this book. The results of numerous studies indicate that leptin is indeed a regulated human hormone.§§Leptin provides a detailed account of the myriad physiological, hormonal, metabolic, immunological, mitogenic and inflammatory modulators and targets of leptin in a single volume. Next follows a comprehensive presentation of the therapeutic trials of recombinant leptin in patients with congenital leptin deficiency, lipodystrophy, hypothalamic amenorrhea, and other emerging areas, including leptin supplementation in leptin-replete subjects, leptin substitution for insulin in diabetic models, and novel combination regimens of leptin and other biogenic peptides. Unanswered questions and future directions in leptin research are highlighted in the Foreword by Dr. Jeffrey Friedman and throughout the volume. Identifying such questions helps direct research that could deepen understanding of the complex regulation of leptin under physiological and pathological conditions, a critical prerequisite to its rational deployment in the treatment of human disorders.§

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Leptin, 1

Regulation and Clinical Applications

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