Microparticle Formation by Spray-Freeze-Drying

Name: Microparticle Formation by Spray-Freeze-Drying
Brand: Sudwestdeutscher Verlag Fur Hochschulschriften AG
SKU: 9783838117713
Price: 26656 HUF
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The Influence of Atomization Conditions on Protein Secondary and Tertiary Structure

Szerző: Sebastian Vonhoff

Nyelv:

Kötés: Puha kötésű

Kiadó: Sudwestdeutscher Verlag Fur Hochschulschriften AG

Elérhetőség: Beszállítói készleten

Küldés 5-8 napon belül

26 656 Ft

This thesis deals with the preparation microparticles by spray-freeze-drying (SFD). As the process c...

Információk a könyvről

Szerző

Sebastian Vonhoff

Nyelv

Angol

Kötés

Könyv - Puha kötésű

Kiadva

2010

oldal

188

EAN

9783838117713

ISBN

3838117719

Enbook ID

07139440

Kiadó

Sudwestdeutscher Verlag Fur Hochschulschriften AG

Súly

281

Méretek

152 x 229 x 12

Teljes leírás

This thesis deals with the preparation microparticles by spray-freeze-drying (SFD). As the process consists of various unit operations, the stability of labile APIs, such as proteins, can be serverly impaired. The secondary structure of a protein is known to be directly linked to its overall stability. However, quantification of protein secondary structure by FTIR spectroscopy can show poor reproducibility. Therefore, the first part of this thesis covers the development of a new FTIR method for objective and fast determination of protein secondary structure. The second part investigates the influence of atomization conditions on protein secondary and tertiary structure as well as residual enzyme activity during SFD. The process is analyzed after a) atomization b) atomization, freezing and thawing and c) the complete SFD process. A thorough comparison of the utilized ultrasound nozzles (including particle size distribution, temperatures and cavitation effects) is performed in the third part of this thesis. In the fourth and last part, different formulations containing a mixture of alpha-chymotrypsin and various excipients are evaluated for their stability.

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Microparticle Formation by Spray-Freeze-Drying

The Influence of Atomization Conditions on Protein Secondary and Tertiary Structure

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Azok a vásárlók, akik ezt a könyvet megvásárolták, a következőket is megvásárolták