Modeling Cancer Progression on the Pathway Level

Name: Modeling Cancer Progression on the Pathway Level
Brand: VDM Verlag Dr. Müller
SKU: 9783639210293
Price: 24068 HUF
Availability: InStock

Assessing Cancer Progression via Pathway Dependencies

Szerző: Elena Edelman

Nyelv:

Kötés: Puha kötésű

Kiadó: VDM Verlag Dr. Müller

Elérhetőség: Kiadói készleten rendelésre

Küldés 17-27 napon belül

24 068 Ft

Over the past several decades, many genes have been discovered that govern important function in the...

Információk a könyvről

Szerző

Elena Edelman

Nyelv

Angol

Kötés

Könyv - Puha kötésű

Kiadva

2009

oldal

176

EAN

9783639210293

Enbook ID

06828958

Kiadó

VDM Verlag Dr. Müller

Súly

278

Méretek

150 x 220 x 11

Teljes leírás

Over the past several decades, many genes have been discovered that govern important function in the development of a variety of different cancers. However, biological insight from the list of genes is still limited and the underlying mechanisms that occur in the cell during tumorigenesis have not been well established. Studying cancer progression in terms of the oncogenic pathways that are responsible for specific actions that change normal cells into tumors is a means for bringing insight onto these issues. The work presented here will uncover mechanisms that are occurring at the pathway level that first initiate tumor formation and then continue through cancer progression and finally metastasis. Using gene expression datasets we utilized novel statistical methods to uncover the pathways that play a role in cancer progression and in what order the pathways become perturbed. These analyses can give a basis for how genetic disruptions serve to alter actions in specific cell types. The results may provide insight that will lead to treatments and preventions. Treatments will use multiple drugs to target the pathways that show an altered state of activity.

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Modeling Cancer Progression on the Pathway Level

Assessing Cancer Progression via Pathway Dependencies

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