This book discusses the ways in which mathematical,§computational, and modelling methods can be used to help understand the dynamics§of intracellular calcium. It presents the general modelling theory as well as a§large number of specific case examples, to show how mathematical modelling can interact§with experimental approaches, in an interdisciplinary and multifaceted approach§to the study of an important physiological control mechanism.§§Genevieve Dupont is a Senior Research Associate at Unite de Chronibiologie Theorique, Universitie Libre de Bruxelles; Martin Falcke is the head of the Mathematical Cell Physiology group at Max Delbruck Center for Molecular Medicine; Vivien Kirk is an Associate Professor in the Department of Mathematics at the University of Auckland; James Sneyd is a Professor in the Department of Mathematics at The University of Auckland.§