Menu
Rendelés állapotának ellenőrzése
Kapcsolat
Könyv Molecular and Genetic Characterization of Parkinson's disease Tamal Sadhukhan

Molecular and Genetic Characterization of Parkinson's disease

Identification of causal variants and modifier loci associated with Indian Parkinson's disease patients

Szerző: Tamal Sadhukhan
Nyelv: Angol
Kötés: Puha kötésű
Kiadó: LAP Lambert Academic Publishing
Elérhetőség: Beszállítói készleten
Küldés 5-8 napon belül
22 325 Ft
Parkinson's disease (PD) is the second most common neurodegenerative disorder. In the present study,...

Információk a könyvről

Szerző
Tamal Sadhukhan
Nyelv
Angol
Kötés
Könyv - Puha kötésű
Kiadva
2016
oldal
160
EAN
9783659897375
Enbook ID
13636466
Kiadó
LAP Lambert Academic Publishing
Súly
255
Méretek
150 x 220 x 10

Teljes leírás

Parkinson's disease (PD) is the second most common neurodegenerative disorder. In the present study, we attempted to understand the molecular basis of pathogenesis of PD in India. During the screening of DJ-1 gene, we found a functional variant, p.Arg98Gln, among six PD patients and two controls, while p.Val35Ile, a novel change, was found in two unrelated patients but none in controls. Moreover, SNP rs7517357 and an 18 bp Ins/Del/Dup polymorphism are found to be associated with PD. Our results demonstrate that DJ-1 mutation accounts for 3.9% among the PD patients of eastern India. Two patients carrying mutations in both PINK1 and DJ-1 exert digenic effect in disease pathogenesis. We did not find any of the prevalent mutations and functional polymorphism of LRRK2 gene in the same cohort. Comprehensive analysis with tag SNP markers suggests that LRRK2 gene has a limited role in the pathogenesis of PD among Indians. Again we evaluated the role of APOE and CTSD polymorphisms in modification of disease risk among Eastern Indians, but no significant association was found. Therefore, our study demonstrated a genetic background study of pathogenesis of PD in eastern Indian population.

Érdekelheti

Welsh Writing from the American Civil War

Jerry Hunter
2 538 Ft

Some Buried Caesar

Rex Stout
3 191 Ft

Complete Sonatas and Fantasies for Solo Piano

Wolfgang Amadeus Mozart
11 055 Ft

Making of Chinese Criminal Law

Ying Ji
25 287 Ft

Azok a vásárlók, akik ezt a könyvet megvásárolták, a következőket is megvásárolták

Deutsches Literatur-Lexikon, Erganzungsband III, Christener - Fowelin

Carl-Ludwig Lang
113 449 Ft

Relatos con vinos de Ronda : historias, quizás ciertas, de las bodegas de Ronda

Andrés Rodríguez González
8 953 Ft

A Holdsugár könyvesbolt rejtélyei

Mónica Gutiérrez
3 976 Ft