Könyv Molecular environment and expression strategy of therapeutic target Temaj Gazmend

Molecular environment and expression strategy of therapeutic target

Szerző: Temaj Gazmend
Nyelv: Angol
Kötés: Puha kötésű
Elérhetőség: Beszállítói készleten
Küldés 5-8 napon belül
20 532 Ft
In molecular medicine, for many years, manipulation of disease genes for therapeutic reason has been...

Információk a könyvről

Szerző
Nyelv
Angol
Kötés
Könyv - Puha kötésű
Kiadva
2017
oldal
128
EAN
9783838153728
Enbook ID
16500592
Súly
200
Méretek
152 x 229 x 8

Teljes leírás

In molecular medicine, for many years, manipulation of disease genes for therapeutic reason has been a major subject. The focus has been on manipulation of gene expression at the level of DNA to change mRNA espression. For reasons of therapeutic feasibility, often expression of mRNA is increased or decreased via viral vectors. However, these strategies rely on resident genetic manipulation and often have unexpected side effects after longer treatment. Therefore, the search for protein therapies, i.e. strategies manipulating the protein expression of a target disease gene has gained attention in bio-medical research. A novel way to manipulate protein expression is to manipulate components of the ribosome, a two subunit molecular ensemble translating mRNAs into proteins. Here, we study a mutation in the LAMB3 gene, encoding a component of a trimeric anchor protein Laminin 322, which links the epidermis and dermis of the skin. LAMB3 R635X harbours a premature termination codon (PTC), which during translation is recognized by the ribosome with concomitant stop of protein synthesis and loss of the protein.

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