Molecular Genetics of Dysregulated pH Homeostasis

Name: Molecular Genetics of Dysregulated pH Homeostasis
Brand: Springer-Verlag New York Inc.
SKU: 9781493953172
Price: 19730 HUF
Availability: InStock

Szerző: Jen-Tsan Ashley Chi

Nyelv:

Kötés: Puha kötésű

Kiadó: Springer-Verlag New York Inc.

Elérhetőség: Beszállítói készleten

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Most biological reactions and functions occur within a narrow range of pH. Any changes in the pH hav...

Információk a könyvről

Szerző

Jen-Tsan Ashley Chi

Nyelv

Angol

Kötés

Könyv - Puha kötésű

Kiadva

2016

oldal

160

EAN

9781493953172

ISBN

1493953176

Enbook ID

13512830

Kiadó

Springer-Verlag New York Inc.

Súly

2642

Méretek

155 x 235 x 10

Teljes leírás

Most biological reactions and functions occur within a narrow range of pH. Any changes in the pH have great impacts on the biological functional at every level, including protein folding, enzymatic activities and proliferation and cell death. Therefore, maintain the pH homeostasis at the local or systemic level is one of the highest priorities for all multicellular organisms. Many redundant mechanisms are in place to maintain the pH homeostasis, a topic that is well covered in the scientific literature and medical textbooks. However, when the pH homeostasis is disrupted in various physiological adaptations and pathological situations, resulting acidity may trigger significant pathophysiological events and modulate disease outcomes. Therefore, understanding how various cells sense and react to acidity have broad impact in a wide variety of human diseases, including cancer, stroke, myocardial infarction and diabetes, renal and infectious diseases. In this book, many investigators have summarized the molecular genetics on the detailed mechanisms by which different mammalian cells sense and response acidity. These chapters cover the acidity with broad impact in biological understanding and human diseases and review various sensing mechanism and cellular responses to pH alterations in both physiological (taste, pain) and pathological settings (ischemia and cancers). Furthermore, these authors present a broad spectrum of investigative approaches to cellular response to acidosis in a in wide variety of human diseases.§

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Molecular Genetics of Dysregulated pH Homeostasis

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