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Könyv Neurotransmitter Transporters Maarten E. A. Reith

Neurotransmitter Transporters

Structure, Function, and Regulation

Szerző: Maarten E. A. Reith
Nyelv: Angol
Kötés: Kemény kötésű
Kiadó: Humana Press Inc.
Elérhetőség: Beszállítói készleten
Küldés 10-13 napon belül
78 540 Ft
Neurotransmission is a multicomponent process. Transmitters, released by neuronal activity, act on p...

Információk a könyvről

Szerző
Maarten E. A. Reith
Nyelv
Angol
Kötés
Könyv - Kemény kötésű
Kiadva
2002
oldal
518
EAN
9780896039452
ISBN
0896039455
Enbook ID
01400913
Kiadó
Humana Press Inc.
Súly
957
Méretek
155 x 235 x 34

Teljes leírás

Neurotransmission is a multicomponent process. Transmitters, released by neuronal activity, act on pre- and postsynaptic receptors, and many books detail advances in the receptor field. In addition, after their release from nerve endings, transmitters are removed from the neuronal vicinity by uptake into neuronal or glial cells by specific tra- porter proteins that have been studied intensely over the last 30 years; this information is scattered throughout numerous publishing vehicles. Therefore, the primary aim of this second edition of N- rotransmitter Transporters: Structure, Function, and Regulation is to offer a comprehensive picture of the characterization of neurotransmitter transporters and their biological roles. The transporter field has moved forward in stages. In the first phase, progress came from the use of substrate or blocker ligands selectively targeting transporters, the application of model systems allowing the study of transmitter tra- port shielded from storage, and the development of mathematical models for describing transport phenomena. In the second phase, roughly covering the last decade, advances in DNA techniques allowed the cloning of numerous genes coding for different transporter proteins. In the current, third stage, a wealth of information is being accumulated in studies relating transporter structure with function, experiments addressing regulation by posttranslational transfor- tion, investigations into transport modulation by trafficking processes and genomic influences, characterization of channel properties of tra- porters by electrophysiological approaches, and the creation of transgenic animals under- or overexpressing a given transporter protein.

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