Könyv Nisin Based Lantibiotic Engineering V. Mohanasrinivasan

Nisin Based Lantibiotic Engineering

A novel approach on biopreservation

Nyelv: Angol
Kötés: Puha kötésű
Elérhetőség: Kiadói készleten rendelésre
Küldés 17-27 napon belül
17 202 Ft
Lantibiotics are ribosomally synthesized polycyclic peptide containing unusual amino acids, which ha...

Információk a könyvről

Nyelv
Angol
Kötés
Könyv - Puha kötésű
Kiadva
2012
oldal
80
EAN
9783659254734
Enbook ID
06956260
Súly
123
Méretek
150 x 220 x 4

Teljes leírás

Lantibiotics are ribosomally synthesized polycyclic peptide containing unusual amino acids, which have binding specificity for bacterial cells, targeting the bacterial cell wall component lipid II to form pores and there by lyses the cell. Nisin is the one of the most studied commonly used lantibiotics. Nisin inhibit the growth of bacteria by inhibiting cell wall synthesis via binding to Lipid II. Nisin have thio esters five ring system. But first three are actively involved in antimicrobial activity. These are binding to pyrophosphate moiety of lipid II. This mode of action is the rationale for design of small nisin derived peptide to obtain novel potential lantibiotics. As conformational constraints the Thioether Bridge was mimicked by alkanes or alkenes by ring closing metathesis.

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