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Könyv Novel (Trans)dermal Drug Delivery Strategies GARVIE-COOK HAZEL

Novel (Trans)dermal Drug Delivery Strategies

Micro- and Nano-scale Assessments

Szerző: GARVIE-COOK HAZEL
Nyelv: Angol
Kötés: Puha kötésű
Kiadó: Springer International Publishing AG
Elérhetőség: Beszállítói készleten alacsony példányszámban
Küldés 13-18 napon belül
41 337 Ft
This work represents an inventive attempt to apply recent advances in nanotechnology to identify and...

Információk a könyvről

Szerző
GARVIE-COOK HAZEL
Nyelv
Angol
Kötés
Könyv - Puha kötésű
Kiadva
2018
oldal
114
EAN
9783319804538
ISBN
9783319804538
Enbook ID
19308755
Kiadó
Springer International Publishing AG
Súly
454
Méretek
155 x 235 x 7

Teljes leírás

This work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. Atomic force microscopy (AFM) measurements of the nanoscale mechanical properties of topical, drug-containing polymeric films enabled the author to identify optimal compositions, in terms of flexibility and substantivity, for application to the skin. To elucidate the enhanced drug release from polyacrylate films incorporating medium chain triglycerides, the author combined AFM studies with the complementary technique of Raman micro-spectroscopy. This experimental strategy revealed that the significant increase in the drug released from these films is the result of a nanoscale two-phase structure. Finally, in experiments examining the microporation of skin using femtosecond laser ablation, the author demonstrated that the threshold at which the skin's barrier function is undermined can be dramatically reduced by the pre-application of ink. The approach allows thermal damage at the pore edge to be minimised, suggesting a very real potential for substantially increasing drug delivery in a minimally invasive fashion.

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