Paraoxonase (PON1) in Health and Disease

Name: Paraoxonase (PON1) in Health and Disease
Brand: Springer-Verlag New York Inc.
SKU: 9781461353584
Price: 39439 HUF
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Basic and Clinical Aspects

Szerző: Lucio G. Costa, Clement E. Furlong

Nyelv:

Kötés: Puha kötésű

Kiadó: Springer-Verlag New York Inc.

Elérhetőség: Beszállítói készleten

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The paraoxonase or PON family of genes resides on human chromosome 7q2t-22 in the order PONt, PON3 a...

Információk a könyvről

Szerző

Lucio G. Costa, Clement E. Furlong

Nyelv

Angol

Kötés

Könyv - Puha kötésű

Kiadva

2012

oldal

216

EAN

9781461353584

ISBN

1461353580

Enbook ID

06796322

Kiadó

Springer-Verlag New York Inc.

Súly

373

Méretek

155 x 235 x 14

Teljes leírás

The paraoxonase or PON family of genes resides on human chromosome 7q2t-22 in the order PONt, PON3 and PON2. PONt was one of the early genes identified as an environmentally relevant gene, in that it is important in determining an individual's sensitivity or resistance to exposure from specific organophosphorus (OP) insecticides. Paraoxonase (PONt) is an A esterase (i. e. , not inhibited by OP compounds) initially identified for its ability to catalytically hydrolyze paraoxon, the toxic metabolite (oxon form) of the insecticide parathion. Evidence accumulated in the past several years has established that this enzyme, which is present at variable levels in liver and serum of different individuals, is an important determinant of sensitivity to toxicity of specific organophosphorus compounds including chlorpyrifos oxon and diazoxon. Recent experiments have pointed out that it is the catalytic efficiency of PONt together with the levels of PONt that are important in determining the degree of resistance. Surprisingly, even though PONt has a higher catalytic efficiency than PONtQ)92 for paraoxon RJ92 hydrolysis, it does not provide significant in vivo protection against an exposure to paraoxon. Interest in this enzyme has also emerged from the finding that it displays genetic polymorphisms in most populations, with a significant number of the individuals in a given population canying a PONt gene that puts them at risk for a specific OP exposure.

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Paraoxonase (PON1) in Health and Disease

Basic and Clinical Aspects

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Teljes leírás

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