Peritoneal Carcinomatosis: Drugs and Diseases

Name: Peritoneal Carcinomatosis: Drugs and Diseases
Brand: Springer-Verlag New York Inc.
SKU: 9781461285304
Price: 78857 HUF
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Szerző: Paul H. Sugarbaker

Nyelv:

Kötés: Puha kötésű

Kiadó: Springer-Verlag New York Inc.

Elérhetőség: Beszállítói készleten

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Peritoneal carcinomatosis dominates the clinical picture of many patients with gastrointestinal, gyn...

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Szerző

Paul H. Sugarbaker

Nyelv

Angol

Kötés

Könyv - Puha kötésű

Kiadva

2011

oldal

288

EAN

9781461285304

ISBN

9781461285304

Enbook ID

06623676

Kiadó

Springer-Verlag New York Inc.

Súly

547

Méretek

178 x 254 x 16

Teljes leírás

Peritoneal carcinomatosis dominates the clinical picture of many patients with gastrointestinal, gynecological and urological cancers. For many of them its dev astating effects contribute directly to their death. Most clinicians consider peritoneal carcinomatosis an incurable metastatic disease and give palliative treatment, re stricted to limited surgery and systemic chemotherapy. Contrary to this view, Paul Sugarbaker and his collegues base their approach on the concept that peritoneal carcinomatosis represents regional tumor spread, similar in its impact on treatment and prognosis to that of lymph node metastases in other malignancies. This concept emphasises the value of regional tumor control, as a potentially curative measure. In this book the combination of aggressive cytoreduction and intraperitoneal chemotherapy to control peritoneal carcinomatosis is extensively explored. Basic to this approach is the observation that most cancer cells show only relative resistence against commonly available drugs, which can be overcome by a sufficient increase of drug concentrations in tumor tissue. After intraperitoneal delivery, drugs will reach high tissue concentrations in the superficial few cell layers, while plasma concentrations will remain below toxic levels. Patients with only limited residual tumor at the peritoneal surface after cytoreduction may therefore benefit from intraperitoneal chemotherapy.

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Peritoneal Carcinomatosis: Drugs and Diseases

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