Prostaglandins and Immunity

Name: Prostaglandins and Immunity
Brand: Kluwer Academic Publishers
SKU: 9780898387230
Price: 63556 HUF
Availability: InStock

Szerző: James S. Goodwin

Nyelv:

Kötés: Kemény kötésű

Kiadó: Kluwer Academic Publishers

Elérhetőség: Beszállítói készleten alacsony példányszámban

Küldés 13-18 napon belül

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Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging are...

Információk a könyvről

Szerző

James S. Goodwin

Nyelv

Angol

Kötés

Könyv - Kemény kötésű

oldal

210

EAN

9780898387230

ISBN

089838723X

Enbook ID

01401291

Kiadó

Kluwer Academic Publishers

Súly

499

Méretek

155 x 235 x 14

Teljes leírás

Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E2 (PGE2), prostacyclin (PGI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di-and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.

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