Purinergic Signalling and the Nervous System

Szerző: Verkhratsky Alexei, Geoffrey Burnstock

Nyelv:

Kötés: Puha kötésű

Kiadó: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

Elérhetőség: Beszállítói készleten

Küldés 5-8 napon belül

78 670 Ft

In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists we...

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Szerző

Verkhratsky Alexei, Geoffrey Burnstock

Nyelv

Angol

Kötés

Könyv - Puha kötésű

Kiadva

2016

oldal

715

EAN

9783662505496

ISBN

3662505495

Enbook ID

18052057

Kiadó

Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

Súly

1861

Méretek

178 x 254 x 40

Teljes leírás

In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents. In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.

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Purinergic Signalling and the Nervous System

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