Pyrazoline Derivatives as Antitubercular Agents

Name: Pyrazoline Derivatives as Antitubercular Agents
Brand: LAP Lambert Academic Publishing
SKU: 9783848406340
Price: 17129 HUF
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Synthesis, Characterization & Evaluation of Some Novel Pyrazoline Derivatives

Szerző: Vaibhav Jain, Priyal Jain, Surendra Jain

Nyelv:

Kötés: Puha kötésű

Kiadó: LAP Lambert Academic Publishing

Elérhetőség: Kiadói készleten rendelésre

Küldés 17-27 napon belül

17 129 Ft

Mycobacterium tuberculosis (MTB), the pathogenic agent of tuberculosis (TB), is responsible for the...

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Szerző

Vaibhav Jain, Priyal Jain, Surendra Jain

Nyelv

Angol

Kötés

Könyv - Puha kötésű

Kiadva

2012

oldal

EAN

9783848406340

Enbook ID

06974974

Kiadó

LAP Lambert Academic Publishing

Súly

153

Méretek

150 x 220 x 6

Teljes leírás

Mycobacterium tuberculosis (MTB), the pathogenic agent of tuberculosis (TB), is responsible for the death of 2 3 million people annually and for a global economic toll of $12 billion each year. Thus, there is an urgent need to develop new therapeutics for tuberculosis, to reduce the duration of treatment and to provide a more effective therapy for MDR TB and for latent tuberculosis infection. In the present investigation, a series of 4-(4-(dimethylamino) benzyl)-3-methyl-1H-pyrazol-5(4H)-one analogues of pyrazole were synthesized by cyclization of mannich base with hydrazine hydrate. The nitrogen functionality of 4-(4-(dimethylamino) benzyl)-3-methyl-1H-pyrazol-5(4H)-one was alkylated with different halogenated alkylated substituted chain in the presence of base. The chemical structure of compounds were proved by IR, MASS, 1HNMR spectroscopy data and elemental analysis. . The antitubercular activity of these compounds were evaluated by microdilution method against M. Tuberculosis H37Rv micobactrium strain of M. Tuberculosis compared with standard INH, RIF & ETM.

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Pyrazoline Derivatives as Antitubercular Agents

Synthesis, Characterization & Evaluation of Some Novel Pyrazoline Derivatives

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Teljes leírás

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Azok a vásárlók, akik ezt a könyvet megvásárolták, a következőket is megvásárolták