This Special Issue focuses on the field of hydropower station operation and management, systematically compiling cutting-edge research findings centered on core themes ranging from safety assurance to performance enhancement. Against the backdrop of advancing global carbon reduction targets and the accelerated development of new power systems, the Special Issue focuses on four key areas: the optimization of multi-energy complementary systems; stability control for hydropower systems; fault diagnosis and structural optimization for hydropower equipment; and reservoir scheduling and disaster prevention and mitigation. The articles included in this collection cover various types of hydropower, including conventional hydropower, cascade hydropower, and pumped-storage hydropower. By integrating multidisciplinary technical approaches such as information science, artificial intelligence, and numerical simulation, the authors present research that combines theoretical innovation with practical engineering value, providing technical support and practical guidance for intelligent upgrading, the safe and efficient operation of hydropower stations, and the development of new power systems. This Reprint contains high-quality papers from the Special Issue, comprehensively showcasing technological advancements and research breakthroughs in the field of hydropower station operation and management, while facilitating academic exchange and industrial applications in related fields.