Short-Term Bioassays in the Analysis of Complex Environmental Mixtures III

Name: Short-Term Bioassays in the Analysis of Complex Environmental Mixtures III
Brand: Springer-Verlag New York Inc.
SKU: 9781461336136
Price: 19729 HUF
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Szerző: Michael D. Waters

Nyelv:

Kötés: Puha kötésű

Kiadó: Springer-Verlag New York Inc.

Elérhetőség: Beszállítói készleten

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In the four years since the 1978 Symposium on the Application of Short-Term Bioassays in the Fractio...

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Szerző

Michael D. Waters

Nyelv

Angol

Kötés

Könyv - Puha kötésű

Kiadva

2011

oldal

589

EAN

9781461336136

ISBN

1461336139

Enbook ID

02180294

Kiadó

Springer-Verlag New York Inc.

Súly

967

Méretek

156 x 244 x 33

Teljes leírás

In the four years since the 1978 Symposium on the Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures the use of short-term bioassays to evaluate potential health hazards of complex environmental mixtures has substantially increased. Increased research activity has been particularly noticeable in mobile source emissions, where initial observations on the mutagenic activity of diesel particulate extracts reported at the 1978 symposium stimulated the development of major research programs in government and industry. In the absence of appropriate reference materials, the U.S. Environmental Protection Agency initiated comparative genotoxicity studies to determine the relative mutagenic and carcinogenic activity and, ultimately, the potential human health risk due to exposure to various complex emission products. Among the materials investigated were those of known health risk, such as coke oven and roofing tar emissions and cigarette smoke condensates, and those of unknown hazard, such as exhaust from diesel-and gasoline-powered vehicles. Studies on diesel emission products proved useful in short term bioassay development, as the diesel exhaust extracts were genetically active with low cellular toxicity and could be obtained in relatively large quantities. Availability of such samples aided chemical characterization, and it was eventually determined that the nitro-polynuclear aromatic hydrocarbons were among the mutagenic components of diesel exhaust particulate.

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Short-Term Bioassays in the Analysis of Complex Environmental Mixtures III

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