Könyv STRUCTURE-ACTIVITY RELATIONSHIPS FOR PHARMACOTOXICOLOGICAL ENDPOINTS Iglika Lessigiarska

STRUCTURE-ACTIVITY RELATIONSHIPS FOR PHARMACOTOXICOLOGICAL ENDPOINTS

DEVELOPMENT OF STRUCTURE-ACTIVITY RELATIONSHIPS FOR PHARMACOTOXICOLOGICAL ENDPOINTS RELEVANT TO EUROPEAN UNION LEGISLATION

Nyelv: Angol
Kötés: Puha kötésű
Elérhetőség: Beszállítói készleten
Küldés 5-8 napon belül
26 361 Ft
Quantitative structure-activity relationships (QSARs) are computer-based mathematical models that gi...

Információk a könyvről

Nyelv
Angol
Kötés
Könyv - Puha kötésű
Kiadva
2010
oldal
232
EAN
9783838356808
Enbook ID
06995262
Súly
362
Méretek
150 x 220 x 14

Teljes leírás

Quantitative structure-activity relationships (QSARs) are computer-based mathematical models that give information on the potential biological effects of compounds on the basis of their chemical structure alone. In this book, a research project on the development of QSARs for a range of toxicological endpoints, including cytotoxicity and acute toxicity, and biokinetic parameters related to the penetration of chemical compounds across the blood-brain barrier, is presented. Increasingly, legislation on the assessment and management of chemical risks, such as the REACH (Registration, Evaluation and Authorisation of Chemicals) Regulation in European Union, foresee an expanded use of QSARs as an alternative approach to (animal) testing of toxicity for the regulatory assessment of chemicals and chemical products. The research presented was performed at the Institute for Health & Consumer Protection (IHCP) of the European Commission's Joint Research Centre (JRC) and at Liverpool John Moores University (LJMU) as a part of Iglika Lessigiarska's PhD project.

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