Structure and Dynamics of Non-Native States of Proteins

Name: Structure and Dynamics of Non-Native States of Proteins
Brand: LAP Lambert Academic Publishing
SKU: 9786202006880
Price: 22346 HUF
Availability: InStock

Szerző: Satish Kumar

Nyelv:

Kötés: Puha kötésű

Kiadó: LAP Lambert Academic Publishing

Elérhetőség: Beszállítói készleten

Küldés 5-8 napon belül

22 346 Ft

Protein aggregation and deposition in different tissues culminates in a wide range of diseases like...

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Szerző

Satish Kumar

Nyelv

Angol

Kötés

Könyv - Puha kötésű

Kiadva

2017

oldal

176

EAN

9786202006880

ISBN

6202006889

Enbook ID

18128400

Kiadó

LAP Lambert Academic Publishing

Súly

278

Méretek

150 x 220 x 11

Teljes leírás

Protein aggregation and deposition in different tissues culminates in a wide range of diseases like Alzheimer's, Parkinson's. Aggregated proteins poses challenges to pharmaceutical industries also, where formation of inclusion bodies reduces the yield and shelf-life of recombinant proteins. Thus understanding the mechanism of protein aggregation and inhibition is urgently required to delineate the pathogenicity linked with several diseases and to circumvent the problems associated with the isolation and long term storage of biopharmaceutical protein drugs. Here, we proposed the aggregation mechanism of hen egg white lysozyme (HEWL) at alkaline condition. We also employed several additives like chemical surfactants and chitotriose, a competitive inhibitor of lysozyme to inhibit the HEWL aggregation at alkaline condition. We not only successfully inhibited the HEWL aggregation but also retained its activity at harsh condition. We also revealed that Thioflavin T is not a specific probe for amyloid but it can show enhanced fluorescence with cellular components. Present work will put a new insight into protein misfolding and aggregation and approaches towards therapeutic intervention.

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Structure and Dynamics of Non-Native States of Proteins

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