Synthesis & Characterization of Coumarin based antimalarial agents

Name: Synthesis & Characterization of Coumarin based antimalarial agents
Brand: LAP Lambert Academic Publishing
SKU: 9783659907463
Price: 12389 HUF
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Synthesis, Characterization & Molecular Modeling Studies of Coumarin based Falcipain-2 Inhibitors as Antimalarial agents

Szerző: Kuldeep Singh Patel, Neerupma Dhiman

Nyelv:

Kötés: Puha kötésű

Kiadó: LAP Lambert Academic Publishing

Elérhetőség: Beszállítói készleten

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Malaria, the most prevalent and most pernicious parasitic disease of humans, is estimated to kill ab...

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Szerző

Kuldeep Singh Patel, Neerupma Dhiman

Nyelv

Angol

Kötés

Könyv - Puha kötésű

Kiadva

2017

oldal

EAN

9783659907463

ISBN

3659907464

Enbook ID

15815513

Kiadó

LAP Lambert Academic Publishing

Súly

142

Méretek

150 x 220 x 5

Teljes leírás

Malaria, the most prevalent and most pernicious parasitic disease of humans, is estimated to kill about two million people, mainly children, each year. Several new drugs along with chloroquine, the first synthetically developed antimalarial drug proved to be a successful cure in the past 50 years. The emergence and spread of resistant parasites to some of the drugs and their combination has made it virtually ineffective in most parts of the world. Few newer drugs like lumefantrine, Maloprim, Primaquine retain efficacy, have limitations and have a high cost. And thus, it is indispensable to discover, design, and develop new drugs with different mechanisms, with diversity in chemical structure and be efficacious against drug resistant strain. In addition to this it should be safe for small children and pregnant women, and be affordable. There are several targets validated for development of antimalarial agents. Falcipain-2 is a cysteine protease enzyme, a validated target for malaria. Several studies confirmed the efficacy of cysteine protease inhibitors in arresting and killing parasites in tissue culture models of parasite replication or cell invasion.

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Synthesis & Characterization of Coumarin based antimalarial agents

Synthesis, Characterization & Molecular Modeling Studies of Coumarin based Falcipain-2 Inhibitors as Antimalarial agents

Információk a könyvről

Teljes leírás

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Azok a vásárlók, akik ezt a könyvet megvásárolták, a következőket is megvásárolták