The Case Series Method: Performance and Design of Vaccine Safety

Name: The Case Series Method: Performance and Design of Vaccine Safety
Brand: VDM Verlag Dr. Müller
SKU: 9783639019797
Price: 28200 HUF
Availability: InStock

Szerző: Patrick Musonda

Nyelv:

Kötés: Puha kötésű

Kiadó: VDM Verlag Dr. Müller

Elérhetőség: Kiadói készleten rendelésre

Küldés 17-27 napon belül

28 200 Ft

The self-controlled case series method (SCCSM) is a §novel study design to investigate associations...

Információk a könyvről

Szerző

Patrick Musonda

Nyelv

Angol

Kötés

Könyv - Puha kötésű

Kiadva

2009

oldal

256

EAN

9783639019797

Enbook ID

06811877

Kiadó

VDM Verlag Dr. Müller

Súly

398

Méretek

150 x 220 x 15

Teljes leírás

The self-controlled case series method (SCCSM) is a §novel study design to investigate associations §between acute responses with transient point §exposures (for example vaccination). The method §provides an attractive alternative to cohort and §case-control designs. The method is unusual in that §it requires data only on individuals who experience §a response (the cases ). The data are then analysed §using a Poisson model, conditional on the total §number of events occurring for each individual. This §conditioning ensures that including only cases does §not bias the relative risk estimator. The self-§controlled case series method has been used §to good effect in many settings, such as MMR vaccine §and autism, oral polio vaccine and intussusception, §MMR vaccine and idiopathic thrombocytopenic purpura, §influenza vaccine and asthma exacerbations. §However, hitherto, limited research had been §undertaken on the statistical properties of the §method in general, and virtually no work had been §undertaken on design issues. All these issues were §explored and consolidated by analysing data on §intussusception and oral polio vaccine from §GlaxoSmithKline (GSK).

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The Case Series Method: Performance and Design of Vaccine Safety

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