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Könyv Glutamate/GABA-Glutamine Cycle ARNE SCHOUSBOE

Glutamate/GABA-Glutamine Cycle

Amino Acid Neurotransmitter Homeostasis

Szerző: ARNE SCHOUSBOE
Nyelv: Angol
Kötés: Puha kötésű
Kiadó: Springer International Publishing AG
Elérhetőség: Beszállítói készleten
Küldés 10-18 napon belül
77 886 Ft
Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids gl...

Információk a könyvről

Szerző
ARNE SCHOUSBOE
Nyelv
Angol
Kötés
Könyv - Puha kötésű
Kiadva
2018
oldal
416
EAN
9783319832081
ISBN
9783319832081
Enbook ID
19433740
Kiadó
Springer International Publishing AG
Súly
652
Méretek
155 x 235 x 24

Teljes leírás

Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term "The Glutamate-Glutamine Cycle." In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book. A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction.

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