The Mast Cell: A Multifunctional Effector Cell

Name: The Mast Cell: A Multifunctional Effector Cell
Brand: Springer
SKU: 9783030241926
Price: 38334 HUF
Availability: InStock

Szerző: Domenico Ribatti

Nyelv:

Kötés: Puha kötésű

Kiadó: Springer

Elérhetőség: Beszállítói készleten

Küldés 8-11 napon belül

38 334 Ft

Mast cells (MC) are phylogenetically old cells which are distributed throughout the human organism....

Információk a könyvről

Szerző

Domenico Ribatti

Nyelv

Angol

Kötés

Könyv - Puha kötésű

Kiadva

2020

oldal

112

EAN

9783030241926

ISBN

3030241920

Enbook ID

37627212

Kiadó

Springer

Súly

227

Méretek

159 x 231 x 6

Teljes leírás

Mast cells (MC) are phylogenetically old cells which are distributed throughout the human organism. MC are found in almost all of the major organs and tissues of the body, particularly in association with connective tissue structures such as blood vessels, lymphatic vessels and nerves, and in proximity to surfaces that interface the external environment, such as those of the respiratory and gastrointestinal system and the skin. This selective accumulation at tissue sites where foreign material attempts to invade the host suggests that MC are among the first cells to initiate defensive mechanisms. MC have long been recognized as key cells of type I hypersensitivity reactions. Several lines of evidence, however, indicate that they not only express critical effector functions in classic IgE-associated allergic disorders, but also play important roles in host defense against parasites, bacteria and perhaps even viruses. Indeed, it is now clear that MC can contribute to host defense in the context of either acquired or innate immune responses through the release of a myriad of pro-inflammatory and immunoregulatory molecules and the expression of a wide spectrum of surface receptors for cytokines and chemokines. Moreover, there is growing evidence that MC exert distinct non-immunological functions, playing a relevant role in tissue homeostasis, remodeling and fibrosis as well as in the processes of tissue angiogenesis.

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The Mast Cell: A Multifunctional Effector Cell

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