Theory of Response-Adaptive Randomization in Clinical Trials

Szerző: Feifang Hu, William F. Rosenberger

Nyelv:

Kötés: Kemény kötésű

Kiadó: John Wiley & Sons Inc

Elérhetőség: Beszállítói készleten

Küldés 10-18 napon belül

56 494 Ft

Presents a firm mathematical basis for the use of response-adaptive randomization procedures in prac...

Információk a könyvről

Szerző

Feifang Hu, William F. Rosenberger

Nyelv

Angol

Kötés

Könyv - Kemény kötésű

Kiadva

2006

oldal

232

EAN

9780471653967

ISBN

0471653969

Enbook ID

04892748

Kiadó

John Wiley & Sons Inc

Súly

514

Méretek

156 x 240 x 19

Teljes leírás

Presents a firm mathematical basis for the use of response-adaptive randomization procedures in practice The Theory of Response-Adaptive Randomization in Clinical Trials is the result of the authors' ten-year collaboration as well as their collaborations with other researchers in investigating the important questions regarding response-adaptive randomization in a rigorous mathematical framework. Response-adaptive allocation has a long history in biostatistics literature; however, largely due to the disastrous ECMO trial in the early 1980s, there is a general reluctance to use these procedures. This timely book represents a mathematically rigorous subdiscipline of experimental design involving randomization and answers fundamental questions, including:* How does response-adaptive randomization affect power?* Can standard inferential tests be applied following response-adaptive randomization?* What is the effect of delayed response?* Which procedure is most appropriate and how can "most appropriate" be quantified?* How can heterogeneity of the patient population be incorporated?* Can response-adaptive randomization be performed with more than two treatments or with continuous responses? The answers to these questions communicate a thorough understanding of the asymptotic properties of each procedure discussed, including asymptotic normality, consistency, and asymptotic variance of the induced allocation. Topical coverage includes:* The relationship between power and response-adaptive randomization* The general result for determining asymptotically best procedures* Procedures based on urn models* Procedures based on sequential estimation* Implications for the practice of clinical trials Useful for graduate students in mathematics, statistics, and biostatistics as well as researchers and industrial and academic biostatisticians, this book offers a rigorous treatment of the subject in order to find the optimal procedure to use in practice.

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Theory of Response-Adaptive Randomization in Clinical Trials

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