Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development

Name: Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development
Brand: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
SKU: 9783642451973
Price: 59226 HUF
Availability: InStock

Szerző: Constanze Bonifer, Peter Cockerill

Nyelv:

Kötés: Kemény kötésű

Kiadó: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

Elérhetőség: Beszállítói készleten

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During vertebrate hematopoiesis many specialized cell types are formed with vastly different functio...

Információk a könyvről

Szerző

Constanze Bonifer, Peter Cockerill

Nyelv

Angol

Kötés

Könyv - Kemény kötésű

Kiadva

2014

oldal

416

EAN

9783642451973

ISBN

3642451977

Enbook ID

02251561

Kiadó

Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

Súly

7686

Méretek

155 x 235 x 29

Teljes leírás

During vertebrate hematopoiesis many specialized cell types are formed with vastly different functions such as B cells, T cells, granulocytes, macrophages, erythrocytes and megakaryocytes. To tightly control the enormous proliferative potential of developing blood cells, an intricately balanced signaling and transcription network has evolved that ensures that the different cell types are formed at the right time and in the right numbers. Intricate regulatory mechanisms ensure that blood cells function properly and have a determined life span. Moreover, in the adaptive immune system, long-lived memory cells have evolved that ensure that when pathogens have been seen once they will never cause a problem again. In this book we will therefore make a journey from asking how more primitive organisms use the epigenetic regulatory machinery to balance growth with differentiation control towards digging deep into what controls the function of specialized cells of the human immune system. We will first discover that flies make blood but exist without blood vessels, why fish make blood cells in the kidney and which precise genetic circuitries are required for these developmental pathways. We will then learn the regulatory principles that drive the differentiation of mature blood cells from stem cells and what controls their function in mammals. In the process, we will find out what unites hematopoietic stem cells and endothelial cells. Finally, we will shed light on the molecular mechanisms that either alter hematopoietic cell differentiation or lead to the development of cells with impaired function.?

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Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development

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