Anaphase promoting complex: structure and expression

Name: Anaphase promoting complex: structure and expression
Brand: LAP Lambert Academic Publishing
SKU: 9783659875595
Price: 21686 HUF
Availability: InStock

Szerző: Hamzeh Rahimi

Nyelv:

Kötés: Puha kötésű

Kiadó: LAP Lambert Academic Publishing

Elérhetőség: Beszállítói készleten

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The anaphase promoting complex (APC) is the largest Cullin-RING E3 ligase that plays a critical role...

Információk a könyvről

Szerző

Hamzeh Rahimi

Nyelv

Angol

Kötés

Könyv - Puha kötésű

Kiadva

2016

oldal

184

EAN

9783659875595

Enbook ID

14441403

Kiadó

LAP Lambert Academic Publishing

Súly

290

Méretek

150 x 220 x 11

Teljes leírás

The anaphase promoting complex (APC) is the largest Cullin-RING E3 ligase that plays a critical role in cell cycle control and known as target of anti-cancer agents. APC regulates the onset of chromosome separation and mitotic exit via securin and cyclin B degradation, respectively. APC controls this process by mediating ubiquitin conjugation to substrates such as cyclin B and securin. The objective of this study was to evaluate the expression pattern of APC subunits in cancer cell lines and AML patients. Moreover, inhibitory compounds were designed based on the 3D structure of the APC and their inhibitory effects were investigated on HeLa and MDA-MB-435 cell lines. To do this, the 3D structure of APC was predicted using homology modelling and molecular dynamic simulation. Interaction among APC subunits were studied by using protein-protein docking methods. It was found that catalytic subunits of APC over-expressed in cancer cell lines and AML patients. Furthermore, the APC subunits assembly and activation was demonstrated at the atomic-level.

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Anaphase promoting complex: structure and expression

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