p53 Tumor Suppressor Pathway and Cancer

Name: p53 Tumor Suppressor Pathway and Cancer
Brand: Springer-Verlag New York Inc.
SKU: 9780387241357
Price: 63556 HUF
Availability: InStock

Szerző: Gerard P. Zambetti

Nyelv:

Kötés: Kemény kötésű

Kiadó: Springer-Verlag New York Inc.

Elérhetőség: Beszállítói készleten alacsony példányszámban

Küldés 13-18 napon belül

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The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. T...

Információk a könyvről

Szerző

Gerard P. Zambetti

Nyelv

Angol

Kötés

Könyv - Kemény kötésű

Kiadva

2005

oldal

246

EAN

9780387241357

ISBN

0387241353

Enbook ID

03612534

Kiadó

Springer-Verlag New York Inc.

Súly

606

Méretek

155 x 235 x 18

Teljes leírás

The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging ?eld ?rst considered p53 as a viral antigen and then as an oncogene that cooperates with activated ras in transforming primary cells in culture. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells. In a simple twist of fate, most of the studies conducted in those early years inadvertently relied on a point mutant of p53 that had been cloned from a normal mouse genomic library. A bona ?de wild-type p53 cDNA was subsequently isolated, ironically, from a mouse teratocarcinoma cell line. A decade after its discovery, p53 was shown to be a tumor suppressor that protects against cancer. It is now recognized that approximately half of all human tumors arise due to mutations within the p53 gene. As remarkable as this number may seem, it signi?cantly underrepresents how often the p53 pathway is targeted during tumorigenesis. It is my personal view, as well as many in the p53 ?eld, that the p53-signaling pathway is corrupted in nearly 100% of tumors. If you are interested in understanding cancer and how it develops, you must begin by studying p53 and its pathway. After demonstrating that p53 functions as a tumor suppressor the ?eld exploded and p53 became a major focus of scientists around the world.

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p53 Tumor Suppressor Pathway and Cancer

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